Polypeptide Tanning Powder Hormone Melanotan II for Bodybuilding
|FOB Price:||US $1 / vails|
|Min. Order:||10 vails|
|Min. Order||FOB Price|
|10 vails||US $1/ vails|
|Port:||Hong Kong, Hong Kong|
|Payment Terms:||T/T, Western Union, Money Gram, bitcoin|
- Model NO.: Melanotan II
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >99%
- Appearance: White Powder
- MOQ: 10 Vials
- Transport Package: According to Client′ Requirement
- Origin: China
- Powder: Yes
- Certification: USP
- State: Solid
- Assay: 99%Min
- Material: Pharmaceutical Raw Material
- Trademark: Yuanhang
- Specification: USP28
- HS Code: 3001200020
|Appearance||White Crystalline Powder|
|Total Plate Count||¡Ü1000cfu/g|
|Yeast & Mold||¡Ü100cfu/g|
|Conclusion||The product conforms to the standard.|
Melanotan-1 Peptide Amino Acid Afamelanotide 10mg/vial MT 1
Melanotan-1 Mechanism of Action:
Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes. Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment). The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP). cAMP in turn activates protein kinase A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein. MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.
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Melanotan 2 Further Information
Melanotan and Melanotan 2 are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that tend to induce skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the additional effect of increasing libido. Melanotan 2 is a cyclic heptapeptide analog of the alpha-melanocyte stimulating hormone (a-MSH).
The effects of Melanotan 2 on the diet and food intake of the laboratory mice have also been investigated. It has been demonstrated that the central melanocortin (MC) has been activated by melanotan 2 when fed and induced in the mice. The six-day treatment of Melanotan 2 has shown that the peptide actually reduced the body weight and the adipose tissue in the viscera of the mice and suppressed the caloric intake of the organism. This has implications in clinical applications of the possible treatment to reduce carbohydrate or calorie intake especially for the overweight and the obese. Furthermore, the same study has also demonstrated that there was a sustained increase in the available oxygen consumption in obese animals. Melanotan 2 also helped reduced the level of serum insulin and the cholesterol levels when compared with the control treatments. Furthermore, it has been suggested that melanotan 2 actually lowers the level of acetylcholine A caboxylase expression and even prevented the reduction of carnitine and palmitoltransferase I mRNA in muscle-type tissues by pair-feeding in the muscles of the obese rats. Moreover, the Melanotan 2 peptide actually increased the fat catabolism in the muscles and even improved the cholesterol metabolism
Dosages and Usage:
Skin Type 1: Very fair skin, never tans. Dosages: 50-60mgs or 5-6vials.
Skin Type 2: Fair skin, burns but sometimes tans. Dosages: 30-40mgs or 3-4 vials.
Skin Type 3: Medium skin, sometimes burns and always tans. Dosages: 20mgs or 2 vials.
Beyond that, if your pigmentation is already naturally olive or darker, you will need to use less Meanotan II for your tanning needs. The tan results coupled with exposure to sunlight and UV rays should last a user all summer or through a season.
Melanotan 2 is a synthetic peptide that studies have demonstrated to exhibit potent tanning (melanogenesis) and libido enhancing effects. Melanotan II is a variant of alpha-melanocyte stimulating hormone (α-MSH), a melanocortin peptide hormone which is produced naturally in the body. Structurally, Melanotan II is a cyclic heptapeptide analog of the alpha-melanocyte stimulating hormone (α-MSH) that tends to induce skin tanning. Melanotan II has the additional effect of increasing libido naturally through stimulation of the melanocortin receptors.
Melanotan 2 has been shown in studies to exhibit appetite suppressant, lipolytic, and libido-enhancing effects in addition to promoting skin tanning. Melanotan 2 has been researched extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis-stimulating properties.
Melanotan II Listeni/mlæntæn/ developed at the University of Arizona is a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that in usage has been shown to have melanogenesis (tanning) and aphrodisiac effects in preliminary studies and clinical trials. It is a cyclic lactam analog of α-MSH with the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.